A recently published study by Klatt and colleagues examined
the impact of choline supplementation alongside DHA
supplementation, versus DHA supplementation alone, on DHA status in
pregnancy.
It is known that DHA is a critical nutrient at this time for
healthy development of the child. And through a number of
mechanisms discussed later, it has been hypothesized that choline
could lead to greater DHA status.
We discuss:
What is the connection between choline and DHA? What is the
PEMT pathway?
Study design for the choline + DHA trial
Are there risks of high-dose choline?
Main findings of the trial
How DHA status is not just a function of DHA intake, but also
methyl metabolism too
Issues with omega-3 trials; e.g. not taking baseline status
into account
Pragmatic recommendations for health professionals and
patients
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